Thank you everyone, your suggestions have been invaluable. It looks like i'm going to go with space lights and 5ks though 6x6 diff frames. Kino's for the talent. Stuart your mention of negative fill is a great pointer, thanks. And Peter and Christopher cheers for the H&S mention.
Manu - i will check that film asap, sounds like a perfect reference and your white cyc and limbo link confirmed my ideas.
Many thanks everyone, fantastic forum.